They prevent pregnancy by suppressing ovulation and changing cervical mucus.
#CONTRACEPTIVE DIANE 35 ACNE PHARMACY SKIN#
Progesterone-only oral contraceptives are not effective in the management of androgen-mediated skin conditions.Ĭombined oral contraceptives contain two hormones, ethinyloestrodiol 20–35 mcg (an oestrogen) and a progesterone. These effects are not always clinically significant. In female pattern hair loss, the results are: They often work better than prior to the medication. Physical methods of hair removal such as waxing, shaving, electrolysis or laser epilation, can be used at the same time as anti-androgens are taken. They can be combined with other topical and oral treatments for acne. In acne, the effects of anti-androgens include: What are the clinical effects of anti-androgen therapy? Rosiglitazone and pioglitazone can cause heart and liver toxicity. Metformin 250 mg to 2 g daily is safe but can cause diarrhoea and should be taken after food in gradually increasing doses. It may also reduce signs of hyperandrogenism. Insulin resistance can be reduced using metformin, mainly prescribed for type 2 diabetes mellitus and obesity / metabolic syndrome. However, we now know that isotretinoin reduces sebum partly by reducing dihyrotestosterone production in the sebaceous gland. Unfortunately, finasteride does not reduce sebum production and is not effective in the treatment of acne. Spironolactone inhibits 5-alpha reductase weakly. Because they also stop oestrogen production, they may lead to menopausal symptoms, headache and osteoporosis.Įxcessive prolactin is reduced by bromocriptine, cabergoline and quinagolide.ĥ-alpha reductase inhibitors include zinc, finasteride, azelaic acid, saw palmetto and other plant extracts.
The combined treatment is not necessary in post-menopausal women. Spironolactone and cyproterone may be effectively combined with cyproterone acetate/ethinyloestradiol or other oral contraceptive agent, partly because they cause menstrual irregularities and partly to prevent pregnancy. It can cause hepatitis and should not be used for skin disorders.
This is normally used as a hormonal antineoplastic agent in males with prostate cancer. This powerful anti-androgen is usually taken on days 1 to 10 of the menstrual cycle (conventionally, day 1 is the first day of menstruation). Cyproterone acetate 50 to 200 mg (Androcur™, Procur™, Siterone™ – available in New Zealand only on a specialist's prescription).Spironolactone 25-200 mg daily (Aldactone™, Spirotone™, Spiractin™), which is most useful in women over the age of 30 years.These contain ethinylestrodiol and desorgestrel, gestodene or norgestimate. Other low-dose combined oral contraceptives with minimal androgen effect.These include cyproterone acetate (co-cyprindiol or Diane™-35, Estelle™ 35 and Ginet-84™), drospirenone (Yasmin™, Yaz™) or dienogest (Valette™). Oral contraceptive (birth control pill) containing ethinylestrodiol ( oestrogen) and an antiandrogenic progesterone.Androgen receptor blockers act on the sebaceous gland and base of the hair follicle.
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